A). Effects of sunitinib and MI-319 on the growth of 786-0 and A498 xenografts. Tumor volume was normalized to the initial volume when treatment began for each individual tumor for each treatment group. Each growth curve represents the mean from 6 mice in each treatment group. B). p53 activation in RCC xenografts. Lysates were from tumors on day 21 after the start of treatment. Lanes represent data from individual tumors for each treatment group. Blots were probed for p53, and the p53 dependent genes hdm2 and p21, as well as hdmx and vinculin.