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Figure 5 | Molecular Cancer

Figure 5

From: Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells

Figure 5

Effects of treatment on CD11b+/Gr-1+MDSC infiltration into 786-0 and A498 xenografts. A). Immunofluoresence data from 786-0 xenografts. In this study, CD11b = red, Gr-1 = blue. Dually expressing cells are magenta colored; tumor nuclei are yellow. B). Bar graph generated from the manual counting of CD11b+/Gr-1+ cells from five individual tumors from each treatment group. Data from both 786-0 and A498 xenografts are shown. C). SDF-1 levels in RCC xenografts. Lysates were from tumors on day 21 after the start of treatment. Lanes represent data from individual tumors for each treatment group.

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