Figure 1

Genomic information of human CHD1L gene (chromodomain helicase/ATPase DNA binding protein 1-like gene). The genomic locus of CHD1L gene is located on the long arm q21 of Chromosome 1 with 53,152 base pairs in length. It is downstream of FMO5 gene (flavin containing monooxygenase 5) and upstream of LOC10030018 (prostaglandin reductase 1 pseudo gene) and LINC00624. CHD1L contains 23 exons (green boxes), which may be transcribed with six transcript variants. The full-length transcript (NM_004284.2) and encoded protein structure is illustrated. CHD1L protein is comprised of two helicase domains (yellow color), a C-terminal macro domain (blue color) and nuclear localization sequence (NLS, purple color). There are two putative phosphorylation sites at the relative C-terminus of the protein: phospho-serine at 636 and 891 amino acids, respectively.