Figure 3

The underlying mechanisms of oncogenic role of CHD1L during tumorigenesis. CHD1L is amplified at Chr1q21 region and overexpressed in tumors (I). The macro domain of CHD1L protein interacts with Nur77 and inhibits the latter’s nuclear to mitochondrial translocation and the subsequent Nur77-mediated caspases’ activation and cell death (II). On the other hand, CHD1L protein may directly bind to the promoter regions of target genes and activate gene transcription, such as ARHGEF9, TCTP and SPOCK1, leading to various biological effects such as cell survival, invasion, metastasis and genome instability (III-V).