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Figure 4 | Molecular Cancer

Figure 4

From: Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms

Figure 4

Rottlerin induced apoptosis in breast CSCs. (a) Breast CSCs were grown in complete stem cell culture medium and treated with Rott (0, 0.5, 1 and 2 μM) for 48 h. The Western blot analysis was performed to measure the expression of Bax, Bcl-2, Bcl-xL, XIAP, cIAP-1, and β-actin. (b) Breast CSCs were grown in complete stem cell culture medium and treated with Rott (0, 0.5, 1 and 2 μM) for 48 h. The Western blot analysis was performed to measure the expression of active caspase-3, active caspase-9, p-AMPK, AMPK, p-Akt, Akt, p-mTOR, mTOR and β-actin.

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