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Table 1 mRNA Expression Profile of CXCR4 and CXCL12 in SHH vs. non-SHH MB

From: Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration

Tumor histology Collection of specimen Patient age at time of specimen collection Patient status SHH or Non-SHH CXCR4 relative mRNA level CXCL12 relative mRNA level
Desmoplastic Diagnostic 1 year DECEASED SHH 5422 1631
Desmoplastic Diagnostic 2 years ALIVE SHH 1745 217
Desmoplastic Diagnostic 5 years ALIVE SHH 6036 1707
Anaplastic Post-Rx 3 years DECEASED SHH 1216 10
Classic Diagnostic 9 months ALIVE SHH 6225 356
Clssic Diagnostic 1 year DECEASED SHH 2050 567
Classic, Diagnostic 2 years DECEASED SHH 3175 909
Classic Post-Rx 2 years DECEASED SHH 4529 623
Classic Diagnostic 4 years ALIVE SHH 3864 463
Classic Diagnostic 5 years ALIVE SHH 4408 149
Classic, M+ Post-Rx 7 years DECEASED SHH 911 2222
  Mean ± SD 3598 ± 1915 805 ± 730
MBEN Diagnostic 3 years ALIVE Non-SHH 138 291
Anaplastic Diagnostic 2 years ALIVE Non-SHH 43 48
Anaplastic Diagnostic 6 years ALIVE Non-SHH 1717 76
Classic Diagnostic 6 months ALIVE Non-SHH 4367 20
Classic Diagnostic 1 year ALIVE Non-SHH 339 200
Classic Diagnostic 2 years ALIVE Non-SHH 107 1144
Classic Diagnostic 2 years ALIVE Non-SHH 240 615
Classic Diagnostic 2 years ALIVE Non-SHH 582 13
Classic Diagnostic 3 years ALIVE Non-SHH 193 92
Classic Diagnostic 5 years DECEASED Non-SHH 185 75
Classic Diagnostic 6 years DECEASED Non-SHH 125 62
Classic Diagnostic 6 years ALIVE Non-SHH 28 43
Classic, M+ Diagnostic 8 years DECEASED Non-SHH 198 116
Classic Diagnostic 11 years ALIVE Non-SHH 73 47
Classic Diagnostic 11 years ALIVE Non-SHH 51 59
Classic Diagnostic 11 years ALIVE Non-SHH 374 55
Classic Diagnostic 12 years ALIVE Non-SHH 69 149
Classic Diagnostic 16 years ALIVE Non-SHH 80 73
  Mean ± SD 495 ± 1041 177 ± 280
  Fold change SHH/Non-SHH + 7X + 5X
SHH MB desmoplastic vs. Non-desmpplastic
Desmoplastic Diagnostic 1 year DECEASED SHH 5422 1631
Desmoplastic Diagnostic 2 years ALIVE SHH 1745 217
Desmoplastic Diagnostic 5 years ALIVE SHH 6036 1707
  Mean ± SD 4401 ± 2321 1185 ± 839
Anaplastic Post-Rx 3 years DECEASED SHH 1216 10
Classic Diagnostic 9 months ALIVE SHH 6225 356
Classic Diagnostic 1 year DECEASED SHH 2050 567
Classic Diagnostic 2 years DECEASED SHH 3175 909
Classic Diagnostic 2 years DECEASED SHH 4529 623
Classic Diagnostic 4 years ALIVE SHH 3864 463
Classic Diagnostic 5 years ALIVE SHH 4408 149
Classic, M+ Post-Rx 7 years DECEASED SHH 911 2222
  Mean ± SD 3297 ± 1822 662 ± 689
  1. SHH MB, sonic-hedgehog medulloblastoma; MBEN, medulloblastoma with extensive nodularity; M+, metastatic; Post-Rx, post-treatment.