Table 1 mRNA Expression Profile of CXCR4 and CXCL12 in SHH vs. non-SHH MB
Tumor histology | Collection of specimen | Patient age at time of specimen collection | Patient status | SHH or Non-SHH | CXCR4 relative mRNA level | CXCL12 relative mRNA level |
|---|---|---|---|---|---|---|
Desmoplastic | Diagnostic | 1 year | DECEASED | SHH | 5422 | 1631 |
Desmoplastic | Diagnostic | 2 years | ALIVE | SHH | 1745 | 217 |
Desmoplastic | Diagnostic | 5 years | ALIVE | SHH | 6036 | 1707 |
Anaplastic | Post-Rx | 3 years | DECEASED | SHH | 1216 | 10 |
Classic | Diagnostic | 9 months | ALIVE | SHH | 6225 | 356 |
Clssic | Diagnostic | 1 year | DECEASED | SHH | 2050 | 567 |
Classic, | Diagnostic | 2 years | DECEASED | SHH | 3175 | 909 |
Classic | Post-Rx | 2 years | DECEASED | SHH | 4529 | 623 |
Classic | Diagnostic | 4 years | ALIVE | SHH | 3864 | 463 |
Classic | Diagnostic | 5 years | ALIVE | SHH | 4408 | 149 |
Classic, M+ | Post-Rx | 7 years | DECEASED | SHH | 911 | 2222 |
|  | Mean ± SD | 3598 ± 1915 | 805 ± 730 | |||
MBEN | Diagnostic | 3 years | ALIVE | Non-SHH | 138 | 291 |
Anaplastic | Diagnostic | 2 years | ALIVE | Non-SHH | 43 | 48 |
Anaplastic | Diagnostic | 6 years | ALIVE | Non-SHH | 1717 | 76 |
Classic | Diagnostic | 6 months | ALIVE | Non-SHH | 4367 | 20 |
Classic | Diagnostic | 1 year | ALIVE | Non-SHH | 339 | 200 |
Classic | Diagnostic | 2 years | ALIVE | Non-SHH | 107 | 1144 |
Classic | Diagnostic | 2 years | ALIVE | Non-SHH | 240 | 615 |
Classic | Diagnostic | 2 years | ALIVE | Non-SHH | 582 | 13 |
Classic | Diagnostic | 3 years | ALIVE | Non-SHH | 193 | 92 |
Classic | Diagnostic | 5 years | DECEASED | Non-SHH | 185 | 75 |
Classic | Diagnostic | 6 years | DECEASED | Non-SHH | 125 | 62 |
Classic | Diagnostic | 6 years | ALIVE | Non-SHH | 28 | 43 |
Classic, M+ | Diagnostic | 8 years | DECEASED | Non-SHH | 198 | 116 |
Classic | Diagnostic | 11 years | ALIVE | Non-SHH | 73 | 47 |
Classic | Diagnostic | 11 years | ALIVE | Non-SHH | 51 | 59 |
Classic | Diagnostic | 11 years | ALIVE | Non-SHH | 374 | 55 |
Classic | Diagnostic | 12 years | ALIVE | Non-SHH | 69 | 149 |
Classic | Diagnostic | 16 years | ALIVE | Non-SHH | 80 | 73 |
|  | Mean ± SD | 495 ± 1041 | 177 ± 280 | |||
| Â | Fold change SHH/Non-SHH | + 7X | + 5X | |||
SHH MB desmoplastic vs. Non-desmpplastic | ||||||
Desmoplastic | Diagnostic | 1 year | DECEASED | SHH | 5422 | 1631 |
Desmoplastic | Diagnostic | 2 years | ALIVE | SHH | 1745 | 217 |
Desmoplastic | Diagnostic | 5 years | ALIVE | SHH | 6036 | 1707 |
|  | Mean ± SD | 4401 ± 2321 | 1185 ± 839 | |||
Anaplastic | Post-Rx | 3 years | DECEASED | SHH | 1216 | 10 |
Classic | Diagnostic | 9 months | ALIVE | SHH | 6225 | 356 |
Classic | Diagnostic | 1 year | DECEASED | SHH | 2050 | 567 |
Classic | Diagnostic | 2 years | DECEASED | SHH | 3175 | 909 |
Classic | Diagnostic | 2 years | DECEASED | SHH | 4529 | 623 |
Classic | Diagnostic | 4 years | ALIVE | SHH | 3864 | 463 |
Classic | Diagnostic | 5 years | ALIVE | SHH | 4408 | 149 |
Classic, M+ | Post-Rx | 7 years | DECEASED | SHH | 911 | 2222 |
|  | Mean ± SD | 3297 ± 1822 | 662 ± 689 | |||