Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration

Liangping Yuan; Hongying Zhang; Jingbo Liu; Joshua B Rubin; Yoon-Jae Cho; Hui Kuo Shu; Matthew Schniederjan; Tobey J MacDonald

doi:10.1186/1476-4598-12-18

Table 2 mRNA profiles of GRK s and PDGFR/PDGF in SHH vs. Non-SHH MB

From: Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration

SHH MB
Pathological diagnosis	Patient status	*GRK4*	*GRK5*	*GRK6*	*PDGFRA*	*PDGFD*	*PDGFA*
Desmoplastic	DECEASED	122	215	65	941	300	666
Desmoplastic	ALIVE	140	154	56	1071	392	236
Desmoplastic	ALIVE	80	77	60	911	417	192
Anaplastic	DECEASED	49	355	117	48	454	226
Classic	ALIVE	108	78	82	723	65	237
Classic	DECEASED	118	184	86	469	139	391
Classic	DECEASED	134	235	59	2166	231	114
Classic	DECEASED	162	1253	75	926	98	471
Classic	ALIVE	60	265	84	405	80	87
Classic	ALIVE	72	148	93	773	310	91
Classic, M+	DECEASED	101	343	71	767	122	182
	Mean ± SD	104 ± 36	301 ± 329	77 ± 18	836 ± 530	237 ± 145	263 ± 179
Non-SHH MB
MBEN	ALIVE	171	245	72	73	155	67
Anaplastic	ALIVE	251	344	69	58	116	102
Anaplastic	ALIVE	272	186	110	21	63	84
Classic	ALIVE	142	624	74	190	10	32
Classic	ALIVE	186	253	76	322	63	111
Classic	ALIVE	192	235	64	406	49	36
Classic	ALIVE	144	666	58	187	52	41
Classic	ALIVE	139	217	71	25	67	125
Classic	ALIVE	143	217	58	43	78	40
Classic	DECEASED	141	293	29	388	100	64
Classic	DECEASED	150	278	51	102	29	16
Classic	ALIVE	252	370	120	145	23	31
Classic, M+	DECEASED	142	454	69	727	79	172
Classic	ALIVE	242	173	70	57	245	35
Classic	ALIVE	207	435	70	49	54	44
Classic	ALIVE	220	731	81	191	58	41
Classic	ALIVE	239	142	42	61	92	84
Classic	ALIVE	285	615	88	7	68	69
	Mean ± SD	195 ± 51	360 ± 186	71 ± 21	170 ± 186	78 ± 54	66 ± 40
	SHH:non-SHH MB	195 ± 51	360 ± 186	71 ± 21	+5X	+3X	+4X
SHH desmoplastic vs. desmoplastic MB
Desmoplastic	DECEASED	122	215	65	941	300	666
Desmoplastic	ALIVE	140	154	56	1071	65	237
Desmoplastic	ALIVE	80	77	60	911	122	182
	Mean ± SD	114 ± 31	149 ± 69	60 ± 5	974 ± 85	162 ± 123	362 ± 265
Anaplastic	DECEASED	49	355	117	48	392	236
Classic	ALIVE	108	78	82	723	417	192
Classic	DECEASED	118	184	86	469	454	226
Classic	DECEASED	134	235	59	2166	139	391
Classic	DECEASED	162	1253	75	926	231	114
Classic	ALIVE	60	265	84	405	98	471
Classic	ALIVE	72	148	93	773	80	87
Classic, M+	DECEASED	101	343	71	767	310	91
	Mean ± SD	101 ± 38	358 ± 374	83 ± 17	785 ± 623	265 ± 149	226 ± 141

SHH MB, sonic-hedgehog medulloblastoma; MBEN, medulloblastoma with extensive nodularity; M+, metastatic.

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