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Table 2 mRNA profiles of GRK s and PDGFR/PDGF in SHH vs. Non-SHH MB

From: Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration

SHH MB
Pathological diagnosis Patient status GRK4 GRK5 GRK6 PDGFRA PDGFD PDGFA
Desmoplastic DECEASED 122 215 65 941 300 666
Desmoplastic ALIVE 140 154 56 1071 392 236
Desmoplastic ALIVE 80 77 60 911 417 192
Anaplastic DECEASED 49 355 117 48 454 226
Classic ALIVE 108 78 82 723 65 237
Classic DECEASED 118 184 86 469 139 391
Classic DECEASED 134 235 59 2166 231 114
Classic DECEASED 162 1253 75 926 98 471
Classic ALIVE 60 265 84 405 80 87
Classic ALIVE 72 148 93 773 310 91
Classic, M+ DECEASED 101 343 71 767 122 182
  Mean ± SD 104 ± 36 301 ± 329 77 ± 18 836 ± 530 237 ± 145 263 ± 179
Non-SHH MB
MBEN ALIVE 171 245 72 73 155 67
Anaplastic ALIVE 251 344 69 58 116 102
Anaplastic ALIVE 272 186 110 21 63 84
Classic ALIVE 142 624 74 190 10 32
Classic ALIVE 186 253 76 322 63 111
Classic ALIVE 192 235 64 406 49 36
Classic ALIVE 144 666 58 187 52 41
Classic ALIVE 139 217 71 25 67 125
Classic ALIVE 143 217 58 43 78 40
Classic DECEASED 141 293 29 388 100 64
Classic DECEASED 150 278 51 102 29 16
Classic ALIVE 252 370 120 145 23 31
Classic, M+ DECEASED 142 454 69 727 79 172
Classic ALIVE 242 173 70 57 245 35
Classic ALIVE 207 435 70 49 54 44
Classic ALIVE 220 731 81 191 58 41
Classic ALIVE 239 142 42 61 92 84
Classic ALIVE 285 615 88 7 68 69
  Mean ± SD 195 ± 51 360 ± 186 71 ± 21 170 ± 186 78 ± 54 66 ± 40
SHH:non-SHH MB +5X +3X +4X
SHH desmoplastic vs. desmoplastic MB
Desmoplastic DECEASED 122 215 65 941 300 666
Desmoplastic ALIVE 140 154 56 1071 65 237
Desmoplastic ALIVE 80 77 60 911 122 182
  Mean ± SD 114 ± 31 149 ± 69 60 ± 5 974 ± 85 162 ± 123 362 ± 265
Anaplastic DECEASED 49 355 117 48 392 236
Classic ALIVE 108 78 82 723 417 192
Classic DECEASED 118 184 86 469 454 226
Classic DECEASED 134 235 59 2166 139 391
Classic DECEASED 162 1253 75 926 231 114
Classic ALIVE 60 265 84 405 98 471
Classic ALIVE 72 148 93 773 80 87
Classic, M+ DECEASED 101 343 71 767 310 91
  Mean ± SD 101 ± 38 358 ± 374 83 ± 17 785 ± 623 265 ± 149 226 ± 141
  1. SHH MB, sonic-hedgehog medulloblastoma; MBEN, medulloblastoma with extensive nodularity; M+, metastatic.
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