Figure 1From: Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoformsQuizartinib inhibits cellular proliferation of KIT -, FLT3 - or PDGFR-dependent leukemia cells. Dilution series of quizartinib for several cell lines harboring mutant-FLT3, ABL1 or PDGFRA (1A) or mutant-KIT isoforms (1B) were performed and cellular proliferation was assessed using an XTT-based assay. Sensitivity towards quizartinib varied widely between the tested cell lines. IC50s and mutation isoforms for all tested cell lines are listed in Table 1.Back to article page