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Figure 5 | Molecular Cancer

Figure 5

From: Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms

Figure 5

Quizartinib selectively induces apoptosis in gastrointestinal stromal tumor (GIST) cells. The imatinib-sensitive cell line GIST822, harboring a KIT K642E mutation (A) and the imatinib-insensitive cell line GIST48, harboring a KIT V560D plus an additional D820A mutation, were treated with quizartinib for 7 days and assayed for induction of apoptosis. Quadrant density dot plots are provided showing the apoptotic cell fraction as indicated by annexin V positivity (LR quadrant: early apoptosis) and/or positive propidium iodide stain (UR: late apoptosis, UL: dead cells) of quizartinib-treated versus treatment-naive cells. Estimated IC50s by non-linear dose regression analysis are provided with Table 2.

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