Cell line | Target | IC50 (nM) |
---|---|---|
Inhibition of proliferation | ||
HMC1.1 | KIT V560G | 14 |
HMC1.2 | KIT V560G/D816V | 1727 |
HMC1.2, 0.5% FBS | KIT V560G/D816V | 263 |
p815 | KIT D814Y (murine) | 445 |
Kasumi-1 | KIT N822K | 36 |
M-07e + SCF | KIT-activated | 77 |
M-07e + GM-CSF | GM-CSF signaling | not reached* |
EOL-1 | FIP1L1-PDGFRA | 1 |
K562 | BCR/ABL | not reached* |
HL60 | unknown | not reached* |
Jurkat | unknown | not reached* |
MV4;11 | FLT3 ITD (hemizygous) | < 1 |
MOLM14 | FLT3 ITD | < 1 |
MOLM14 + DMSO | FLT3 ITD | not reached* |
Pat.221 | CBF AML (KIT WT) | 675 |
Pat.279 | CBF AML (KIT WT) / FLT3 amplification (subclone)? | 3434 |
Pat.299 | CBF AML (KIT WT) | 7248 |
Pat.305 | CBF AML (KIT WT) | 7079 |
Pat.375 | CBF AML (KIT N/A) | 503 |
Pat.379 | CBF AML (KIT WT) | 806 |
Pat.368 | FLT3 amplification ? | 2700 |
Pat.601 | FLT3 ITD | 1153 |
Pat.176 | FLT3 ITD (Beta1) | not reached* |
Pat.602 | FLT3 ITD (Beta1) | not reached* |