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Figure 2 | Molecular Cancer

Figure 2

From: PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha

Figure 2

Reduction of AIB1 protein level by PTEN via PI3K/AKT signaling pathway. (A) COS-7 cells transfected with Flag-tagged AIB1 and siRNA against PTEN were treated without or with 10 μM LY294002 for 12 h, and then subjected to western blot analysis with the indicated antibodies. (B) COS-7 cells transfected with Flag-tagged AIB1 alone or together with Gfp-tagged PTEN or/and Ha-tagged AKT (E40K), and then subjected to western blot analysis with the indicated antibodies.

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Molecular Cancer

ISSN: 1476-4598