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Figure 5 | Molecular Cancer

Figure 5

From: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation

Figure 5

Timp1 neutralization renders melanoma cells sensitive to anoikis. Non-metastatic 4C11- (A) and metastatic 4C11+ (B) melanoma cell lines were maintained in suspension for 96 hours in the presence or absence of Timp1-neutralizing antibody. After 96 hours, suspended cells were plated and after 5 days clonogenic capacity was analyzed. 4C11-: non-metastatic melanoma cells; 4C11+: metastatic melanoma cells; NT: non-treated; nTimp1: Timp1-neutralizing antibody. ****p < 0.0001.

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Molecular Cancer

ISSN: 1476-4598