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Table 2 Summary of different metabolites between esophageal cancers and normal mucosae

From: 1H-NMR based metabonomic profiling of human esophageal cancer tissue

Metabolite Chemical shift(ppm) Esophageal cancer vs Normal control
   VIPa p-valueb FCc
Amino acid     
Creatine 3.04 2.18 <0.0001 −1.76
  3.94 2.24 <0.0001 −1.78
NAA 2.02 2.07 <0.0001 1.68
  2.6 1.13 <0.0001 1.71
Glycine 3.56 2.07 <0.0001 −1.64
Glutamine 2.14 1.21 <0.0001 −1.34
  2.45 1.93 <0.0001 −1.56
Glutamate 2.05 1.71 <0.0001 1.33
  2.36 1.17 <0.0001 1.23
Valine 0.98 1.70 <0.0001 1.49
Leucine/Isoleucine 0.96 1.61 <0.0001 1.44
4-HPPA 2.45 1.53 <0.0001 −1.60
L-tyrosine 6.93 1.44 <0.0001 1.63
  7.22 1.29 <0.0001 1.51
Phenylacetylglycine 3.68 1.43 <0.0001 −1.86
  7.35 1.06 <0.0001 1.31
  7.42 1.19 <0.0001 1.45
Methionine 2.11 1.21 <0.0001 1.26
  2.16 1.37 <0.0001 1.54
  2.6 1.13 <0.0001 1.71
Creatinine 3.04 2.18 <0.0001 −1.76
  4.05 1.98 <0.0001 −1.57
Phenylalanine 3.12 1.37 <0.0001 1.42
  7.42 1.19 <0.0001 1.45
GABA 1.91 1.23 <0.0001 3.09
  3.01    
Phenylacetyglutamine 7.42 1.19 <0.0001 1.45
Glutamate γ-H 2.36 1.17 <0.0001 1.23
Taurine 3.43 1.02 <0.0001 1.32
L-aspartate 3.92 1.01 0.0451 −1.15
Lipid     
Myo-inositol 3.55 2.11 <0.0001 −1.97
  3.63 2.07 <0.0001 −1.97
  4.07 1.98 <0.0001 −1.57
Unsaturated lipids 2.27 2.08 <0.0001 1.70
Cho 4.05 1.98 <0.0001 −1.57
Short-chain fatty acids 1.04 1.58 <0.0001 1.49
Choline 4.05 1.98 <0.0001 −1.57
  3.51 1.39 <0.0001 −1.45
Phosphocholine 3.22 1.16 <0.0001 1.24
Carbohydrate     
Glucose 3.25   0.026 −1.16
  3.53 2.11 <0.0001 −1.97
Glycoprotein 2 2.08 <0.0001 1.70
Polyol     
Ethanol 3.65 2.07 <0.0001 −1.97
Acetone 2.22 1.28 <0.0001 1.56
Organic acid     
α-ketogultaric acid oxime 2.44 1.53 <0.0001 −1.60
  2.48 1.93 <0.0001 −1.56
Malonate 3.16 1.34 <0.0001 1.46
Acetoacetic acid 2.27 1.27 <0.0001 1.25
  3.43 1.02 <0.0001 1.32
Acetate 1.92 1.23 <0.0001 3.09
Trimethylamine 2.88 1.19 <0.0001 2.19
Formate 8.45 1.01 0.0005 8.79
Nucleotide     
Uracil 5.81 1.82 <0.0001 39.93
  7.54 1.26 <0.0001 2.13
AMP 6.15 1.76 <0.0001 −2.05
  8.67 1.19 <0.0001 −3.10
NAC1 2.1 1.15 <0.0001 1.49
Adenine in ATP/ADP and NAD/NADH 8.25 1.56 <0.0001 1.41
  8.27 1.58 <0.0001 1.75
  8.36 1.45 <0.0001 1.97
NAC2 2.04 1.69 <0.0001 1.68
Cofactors and vitamins     
NAD 8.83 1.65 <0.0001 −2.81
  9.15 1.49 <0.0001 −2.44
  9.35 1.53 <0.0001 −2.43
Inorganic acid     
Acetyl hydrazine 1.96 1.63 <0.0001 2.14
Xenobiotics     
Hippurate 7.55 1.00 0.0005 1.77
  7.64    
  1. aVariable importance in the projection (VIP > 1) was obtained from OPLS-DA analysis.
  2. bp-value determined from Student's t-test.
  3. cFC: fold change between esophageal cancers and normal mucosae. Positive sign indicates a higher level in esophageal cancer and a negative value indicates a lower level.