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Table 2 Summary of different metabolites between esophageal cancers and normal mucosae

From: 1H-NMR based metabonomic profiling of human esophageal cancer tissue

Metabolite

Chemical shift(ppm)

Esophageal cancer vs Normal control

  

VIPa

p-valueb

FCc

Amino acid

    

Creatine

3.04

2.18

<0.0001

−1.76

 

3.94

2.24

<0.0001

−1.78

NAA

2.02

2.07

<0.0001

1.68

 

2.6

1.13

<0.0001

1.71

Glycine

3.56

2.07

<0.0001

−1.64

Glutamine

2.14

1.21

<0.0001

−1.34

 

2.45

1.93

<0.0001

−1.56

Glutamate

2.05

1.71

<0.0001

1.33

 

2.36

1.17

<0.0001

1.23

Valine

0.98

1.70

<0.0001

1.49

Leucine/Isoleucine

0.96

1.61

<0.0001

1.44

4-HPPA

2.45

1.53

<0.0001

−1.60

L-tyrosine

6.93

1.44

<0.0001

1.63

 

7.22

1.29

<0.0001

1.51

Phenylacetylglycine

3.68

1.43

<0.0001

−1.86

 

7.35

1.06

<0.0001

1.31

 

7.42

1.19

<0.0001

1.45

Methionine

2.11

1.21

<0.0001

1.26

 

2.16

1.37

<0.0001

1.54

 

2.6

1.13

<0.0001

1.71

Creatinine

3.04

2.18

<0.0001

−1.76

 

4.05

1.98

<0.0001

−1.57

Phenylalanine

3.12

1.37

<0.0001

1.42

 

7.42

1.19

<0.0001

1.45

GABA

1.91

1.23

<0.0001

3.09

 

3.01

   

Phenylacetyglutamine

7.42

1.19

<0.0001

1.45

Glutamate γ-H

2.36

1.17

<0.0001

1.23

Taurine

3.43

1.02

<0.0001

1.32

L-aspartate

3.92

1.01

0.0451

−1.15

Lipid

    

Myo-inositol

3.55

2.11

<0.0001

−1.97

 

3.63

2.07

<0.0001

−1.97

 

4.07

1.98

<0.0001

−1.57

Unsaturated lipids

2.27

2.08

<0.0001

1.70

Cho

4.05

1.98

<0.0001

−1.57

Short-chain fatty acids

1.04

1.58

<0.0001

1.49

Choline

4.05

1.98

<0.0001

−1.57

 

3.51

1.39

<0.0001

−1.45

Phosphocholine

3.22

1.16

<0.0001

1.24

Carbohydrate

    

Glucose

3.25

 

0.026

−1.16

 

3.53

2.11

<0.0001

−1.97

Glycoprotein

2

2.08

<0.0001

1.70

Polyol

    

Ethanol

3.65

2.07

<0.0001

−1.97

Acetone

2.22

1.28

<0.0001

1.56

Organic acid

    

α-ketogultaric acid oxime

2.44

1.53

<0.0001

−1.60

 

2.48

1.93

<0.0001

−1.56

Malonate

3.16

1.34

<0.0001

1.46

Acetoacetic acid

2.27

1.27

<0.0001

1.25

 

3.43

1.02

<0.0001

1.32

Acetate

1.92

1.23

<0.0001

3.09

Trimethylamine

2.88

1.19

<0.0001

2.19

Formate

8.45

1.01

0.0005

8.79

Nucleotide

    

Uracil

5.81

1.82

<0.0001

39.93

 

7.54

1.26

<0.0001

2.13

AMP

6.15

1.76

<0.0001

−2.05

 

8.67

1.19

<0.0001

−3.10

NAC1

2.1

1.15

<0.0001

1.49

Adenine in ATP/ADP and NAD/NADH

8.25

1.56

<0.0001

1.41

 

8.27

1.58

<0.0001

1.75

 

8.36

1.45

<0.0001

1.97

NAC2

2.04

1.69

<0.0001

1.68

Cofactors and vitamins

    

NAD

8.83

1.65

<0.0001

−2.81

 

9.15

1.49

<0.0001

−2.44

 

9.35

1.53

<0.0001

−2.43

Inorganic acid

    

Acetyl hydrazine

1.96

1.63

<0.0001

2.14

Xenobiotics

    

Hippurate

7.55

1.00

0.0005

1.77

 

7.64

   
  1. aVariable importance in the projection (VIP > 1) was obtained from OPLS-DA analysis.
  2. bp-value determined from Student's t-test.
  3. cFC: fold change between esophageal cancers and normal mucosae. Positive sign indicates a higher level in esophageal cancer and a negative value indicates a lower level.
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Molecular Cancer

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