From: IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus
 | No. of patients |  | |
---|---|---|---|
 | IHC-IL-6(-) | IHC- IL-6 (+) | p value |
patients | 85 | 88 | Â |
Age | Â | Â | Â |
> = 56y/0 | 43 | 44 | 0.938 |
<56y/o | 42 | 44 | Â |
Location | Â | Â | Â |
Upper third | 22 | 26 | 0.498 |
Middle third | 48 | 42 | Â |
Lower third | 15 | 20 | Â |
Tumor stage | Â | Â | 0.041* |
I-II | 28 | 17 | Â |
III-IV | 57 | 71 | Â |
LN metastasis | Â | Â | 0.246 |
negative | 27 | 21 | Â |
positive | 58 | 67 | Â |
P-stat3 staining | Â | Â | <0.0001* |
negative | 71 | 20 | Â |
positive | 14 | 68 | Â |
Response to Neoadjuvant Tx | Â | Â | 0.0001* |
Response | 69 | 47 | Â |
Non- response | 16 | 41 | Â |
Surgery s/p Neoadjuvant Tx | Â | Â | 0.145 |
Yes | 31 | 24 | Â |
No | 54 | 64 | Â |
Local-regional Recurrence /persistent | Â | Â | <0.0001* |
No | 44 | 16 | Â |
Yes | 41 | 72 | Â |
Distant metastasis | Â | Â | 0.0003* |
negative | 58 | 36 | Â |
positive | 27 | 52 | Â |