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Table 1 Clinico-pathological characteristics of esophageal cancer patients for immunohistochemical investigation

From: IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus

 

No. of patients

 
 

IHC-IL-6(-)

IHC- IL-6 (+)

p value

patients

85

88

 

Age

   

> = 56y/0

43

44

0.938

<56y/o

42

44

 

Location

   

Upper third

22

26

0.498

Middle third

48

42

 

Lower third

15

20

 

Tumor stage

  

0.041*

I-II

28

17

 

III-IV

57

71

 

LN metastasis

  

0.246

negative

27

21

 

positive

58

67

 

P-stat3 staining

  

<0.0001*

negative

71

20

 

positive

14

68

 

Response to Neoadjuvant Tx

  

0.0001*

Response

69

47

 

Non- response

16

41

 

Surgery s/p Neoadjuvant Tx

  

0.145

Yes

31

24

 

No

54

64

 

Local-regional Recurrence /persistent

  

<0.0001*

No

44

16

 

Yes

41

72

 

Distant metastasis

  

0.0003*

negative

58

36

 

positive

27

52

 
  1. Abbreviations: Neoadjuvant Tx = neoadjuvant chemoradiotherapy.