Figure 6

Metabolic profiling of human HT29 colon cancer cells treated with cardiotonic steroids. A: Extracellular lactate concentrations and B: O₂ consumption rates in HT29 cancer cells treated with the indicated compounds at their IC₅₀in vitro growth inhibitory concentrations (see Table 1). The data (mean ± SEM from triplicates) are expressed in mM lactate accumulated in the extracellular medium after 24 hours and arbitrary units derived from time-resolved fluorescent signal.min^-1.