RAL inhibits TAM-resistant T47D:A18/PKCα xenograft tumors. Xenograft tumors were formed as described in materials and methods. Treatments for TAM and RAL were given by oral gavage 5 days/week. A. T47D:A18/PKCα tumors. Mice (10/group) were given TAM (1.5 mg/day) or RAL (0.5 mg/day or 1.5 mg/day). B. LT-TAM-treated T47D:A18/PKCα tumors. Mice (10/group) received TAM (1.5 mg/day) or RAL (1.5 mg/day). C. T47D:A18/neo tumors. Mice (6/group) were given no treatment, E2 capsule (1.0 cm), TAM (1.5 mg/day) or RAL (1.5 mg/day). The dotted line indicates initiation of TAM or RAL treatment following 8 weeks of E2 treatment. Error bars represent SEM.