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Figure 5 | Molecular Cancer

Figure 5

From: Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity

Figure 5

Model of CARM1 interaction with HER2 and EGFR. A STRING database interaction network is modified to indicate putative interaction paths between CARM1 to HER2 and CARM1 to EGFR. Dashed red line highlights a potential physical connection through protein-protein binding of CARM1 in complex with HER2. The dashed green line indicates a potential functional connection to EGF through both post-translational modifications and physical interaction with EGFR complexes. In an ER-negative tumor, the ESR1 interaction is absent; therefore the interaction would occur through CTNNB1. The evidence box shows the source and type of data used to designate the protein interactions.

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Molecular Cancer

ISSN: 1476-4598