TQ-high reduces large tumors in the small intestine (SI). Size distribution of polyps in the SI (A) and colon (B) of APCMin mice (small <0.3 mm; medium: 0.3–1 mm; large: >1 mm). Bars show mean number (± SD) of SI or colonic polyps/mouse. TQ-high (n=16) but not TQ-low (n=13) decreased the number of large polyps in the SI. Piroxicam (n=15) decreased the number of medium and large SI polyps. TQ-high and piroxicam show a trend for reduction of colonic polyps (B) *p<0.05, ***p<0.001; ANOVA, Dunnett 2-sided. Representative H&E-stained Swiss rolls from different treatment groups: untreated (C, n=17), TQ-high (D) and piroxicam (E). Arrows indicate SI polyps of different size.