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Figure 8 | Molecular Cancer

Figure 8

From: Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells

Figure 8

Model depicting the molecular mechanism of ATRA resistance in lung cancer. ATRA promotes RARα recruitment to the membrane, where it activates the PI3k-Akt pathway (1–2). Akt activation promotes cellular survival and cellular invasion (3). Akt represses RARβ2 and p53 expression (4). PI3k-Akt inhibition restores sensitivity to ATRA treatment and blocks survival and invasion (5).

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Molecular Cancer

ISSN: 1476-4598