Table 2 Leukemia models: Comparison of response rates and AKT expression levels
From: Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia
Pt. Nr. | p-AKT (Thr308) expression | p-AKT (Ser473) expression | pan-AKT expression | Mean overall expression | Apoptosis BEZ235 | Proliferation BEZ235 | Apoptosis BGT226 | Proliferation BFT226 |
|---|---|---|---|---|---|---|---|---|
Normalised to mean expression of all donors | GeoMean (pT308+pS473+panAK) | IC50 (nM) | IC50 (nM) | IC50 (nM) | IC50 (nM) | |||
538 (donor) | 0,8 | 0,7 | 0,8 | 0,77 | Not reached | 1779 | ||
554 (donor) | 0,9 | 1,0 | 0,7 | 0,87 | Not reached | 3814 | ||
290 | 1,7 | 1,5 | 2,4 | 1,82 | 71 | 4 | ||
368 | 1,9 | 2,7 | 1,5 | 1,96 | 3182 | 149 | ||
527 | 0,8 | 1,9 | 1,3 | 1,25 | 6824 | 12 | ||
528 | 2,4 | 2,5 | 1,5 | 2,07 | 371 | 12 | ||
532 | 2,8 | 1,2 | 1,2 | 1,59 | 653 | 25 | ||
552 (donor) | 1,3 | 1,3 | 1,5 | 1,34 | 1019 | 1081 | ||
303 | 0,9 | 1,6 | 2,0 | 1,38 | 6142 | 5590 | ||
556 | 1,5 | 1,9 | 1,2 | 1,48 | 24 | 32 | ||