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Table 2 Leukemia models: Comparison of response rates and AKT expression levels

From: Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia

Pt. Nr. p-AKT (Thr308) expression p-AKT (Ser473) expression pan-AKT expression Mean overall expression Apoptosis BEZ235 Proliferation BEZ235 Apoptosis BGT226 Proliferation BFT226
  Normalised to mean expression of all donors GeoMean (pT308+pS473+panAK) IC50 (nM) IC50 (nM) IC50 (nM) IC50 (nM)
538 (donor) 0,8 0,7 0,8 0,77 Not reached 1779
554 (donor) 0,9 1,0 0,7 0,87 Not reached 3814
290 1,7 1,5 2,4 1,82 71 4
368 1,9 2,7 1,5 1,96 3182 149
527 0,8 1,9 1,3 1,25 6824 12
528 2,4 2,5 1,5 2,07 371 12
532 2,8 1,2 1,2 1,59 653 25
552 (donor) 1,3 1,3 1,5 1,34   1019   1081
303 0,9 1,6 2,0 1,38   6142   5590
556 1,5 1,9 1,2 1,48   24   32