Figure 5
From: Novel mechanism of regulation of fibrosis in kidney tumor with tuberous sclerosis
Deficiency of tuberin and activation of mTOR result in increased YY1 protein expression in tumor kidney tissue of TSC patients. (A) Representative Immunoblot analysis showed significant decreased in tuberin and increased in phospho-p70S6K as well as YY1 protein expression in tumor kidney (T) from patients with tuberous sclerosis compared to normal kidney tissues. Actin was used as loading control. (B &C’) Histograms represent means ± SE (n = 6). Significant difference from control is indicated by **P < 0.01.