Skip to main content
Figure 4 | Molecular Cancer

Figure 4

From: BCL11A overexpression predicts survival and relapse in non-small cell lung cancer and is modulated by microRNA-30a and gene amplification

Figure 4

BCL11A gene amplification is frequently observed in squamous cell carcinoma. (A) Chromosome and gene views of copy number variance (CNV) signals in NSCLC with different histological origins. Log2 ratios of CNV probe intensity are plotted on the x axis against genomic location on the y axis. The blue horizontal line represents the location of the BCL11A gene on chromosome 2. a, b, and c represent the chromosome views of squamous cell carcinoma, adenocarcinoma, and large cell carcinoma, respectively. d, e, and f represent the gene views of squamous cell carcinoma, adenocarcinoma, and large cell carcinoma, respectively, which show a zoom-in view of BCL11A copy number variation on the 2p16.1 band. (B) Expression levels were compared between SCC samples without high copy number amplification (SCC-) and SCC with high copy number amplification (SCC+) of the genomic region harboring the gene of interest.

Back to article page

Molecular Cancer

ISSN: 1476-4598