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Figure 7 | Molecular Cancer

Figure 7

From: Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner

Figure 7

Schematic diagram of Hh signaling activation under hypoxia condition. Hypoxia could trigger SMO without affecting SHH or PTCH1 expression. This results in eventual inhibition of factors that promote Gli1 phosphorylation/degradation, and permits cellular accumulation of Gli1. Moreover, hypoxia may trigger other factors, such as TGF-β, KRAS and RTK, to activate GLI1 directly via mechanisms that may operate independently of SMO. Nuclear accumulation of Gli1, in turn, influences transcriptional activity of target genes.

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Molecular Cancer

ISSN: 1476-4598