From: Role of SIRT3 in the regulation of redox balance during oral carcinogenesis
 | SIRT3 | |||
---|---|---|---|---|
 | WT | V208I | P345R | H248Y |
NAD + V max (pmole/min/mg) | 16.03 ± 0.02 | 12.14 ± 0.06 | 15.94 ± 0.14 | 1.08 ± 0.16 |
     K M (mM) | 0.88 ± 0.01 | 1.07 ± 0.03 | 0.88 ± 0.07 | N.D. |
Catalytic efficiency (V max /K M ) | 18.21 | 11.35 | 18.11 | N.D. |
Peptide V max (pmole/min/mg) | 17.5 ± 0.69 | 12.5 ± 0.03 | 17.32 ± 0.45 | 1.32 ± 0.11 |
     K M (mM) | 147.3 ± 12.4 | 153.4 ± 17.5 | 146.8 ± 10.8 | 54.2 ± 14.0 |
Catalytic efficiency (V max /K M ) | 0.11 | 0.07 | 0.12 | 0.02 |