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Table 1 IC50 values of selected cell lines for the panel of TKI

From: A gene expression profile indicative of early stage HER2 targeted therapy response

 

Cell line name

IC50± SD (μM) lapatinib

IC50± SD (μM) neratinib

IC50± SD (μM) afatinib

Lapatinib Sensitive Cell Lines

BT474

0.036 ± 0.015

0.0019 ± 0.00046

0.00323 ± 0.00075

 

SKBR3

0.080 ± 0.017

0.00226 ± 0.00008

0.0075 ± 0.005

Lapatinib Insensitive Cell Line

MDAMB453

6.08 ± 0.825

0.820 ± 0.140

1.59 ± 0.179

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Molecular Cancer

ISSN: 1476-4598