Figure 3

Heat maps of r-subgroups. Heat map of the 6-GeneSig (ALK, BIRC5, CCND1, MYCN, NTRK1, and PHOX2B), ERBB-genes (EGFR, ERBB2, and ERBB3) and 15 TS-genes (Tumour suppressor candidate genes) for all four data sets. The heat map colour scale is based on standard deviations (sd) of all cases in each data set separately, and ranges from sd = 2 (red) to sd = -2 (green). The lower panel represents clinical and biological markers: Histopathology, NB = Neuroblastoma, GNB = ganglioneuroblastoma, GN = ganglioneuroma; Stage INSS, clinical stages 1–4, and 4S according to the international staging system, na = not available; Event = dead of disease, MNA = MYCN amplification, Del1p = 1p deletion, Del11q = 11q deletion, Gain17q = gain of 17q. Colour coding: white = no event, black = event, grey = not available.