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Figure 1 | Molecular Cancer

Figure 1

From: The evolution of malignant and reactive γδ + T cell clones in a relapse T-ALL case after allogeneic stem cell transplantation

Figure 1

One TCR δ clone was identified by FT-CGH, LM-PCR and sequencing in a T-ALL case, and a V δ 5D δ 2J δ 1 rearrangement was confirmed. A: FT-CGH analysis results for the TCR αδ locus in chromosome 14 with arrows indicating the breakpoints. B: Comparison of the GenBank sequences within the Vδ5, Dδ2, and Jδ1 segments. C: Sequence of the Vδ5Dδ2Jδ1 splice junction from a purified LM-PCR product. The sequences within the ellipse indicate the CDR3 segment including the Dδ2 and N regions.

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