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Figure 1 | Molecular Cancer

Figure 1

From: The regulation of toll-like receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells

Figure 1

High TLR2 levels are associated with malignant transformation and lower overall survival in CRC patients. (A) Expression of TLR2 in 39 pairs of tumour samples and matched adjacent noncancerous tissues was measured by real-time PCR. (B) Expression of TLR2 was determined by real-time PCR in 3 normal colon epithelial cells and 4 CRC cell lines (SW480, LS174T, SW620, and HCT116). (C) Expression of TLR2 was determined in 79 CRC tissues (grade1 n = 18; grade2 n = 20; grade3 n = 41) by real-time PCR. The statistical method analysed the correlation between the expression of TLR2 and tumour pathological grade. (D) Expression of TLR2 was checked in 79 CRC tissues (N0 n = 28; N1 n = 31; N2 n = 20) by real-time PCR. The statistical method analysed the correlation between the expression of TLR2 and tumour lymph node metastasis. (E) Lower overall survival of patients with high TLR2 levels (above median; n = 37) compared to patients with low TLR2 levels (below median; n = 42). (***p < 0.001; **p < 0.01; *p < 0.05).

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Molecular Cancer

ISSN: 1476-4598