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Table 3 Associations of TNF-α SNPs with risk of HPV16-associated OSCC

From: Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma

  

Patients

Controls

Adjusted OR (95% CI)1

  

(n = 325)

(n = 335)

   

Variables

HPV16 Status

No.

%

No.

%

OSCC

SCCOP

Oral cavity

TNF-α-308

        

  GG

70

21.5

109

32.5

1.0

1.0

1.0

  GA + AA

155

47.7

184

54.9

1.3 (1.0 − 1.9)

1.4 (1.0 − 2.3)

0.4 (0.1 − 1.5)

  GG

+

31

9.5

19

5.7

2.5 (1.3 − 4.8)

4.6 (2.2 − 9.5)

1.1 (0.7 − 1.8)

  GA + AA

+

69

21.2

23

6.9

4.8 (2.7 − 8.4)

9.3 (4.9 − 17.6)

1.2 (0.5 − 2.8)

TNF-α-857

        

  CC

198

60.9

261

77.9

1.0

1.0

1.0

  CT + TT

27

8.3

32

9.6

1.2 (0.7 − 2.1)

1.4 (0.7 − 2.7)

0.7 (0.3 − 1.4)

  CC

+

85

26.2

38

11.3

3.0 (2.0 − 4.7)

5.6 (3.5 − 9.0)

1.0 (0.5 − 1.9)

  CT + TT

+

15

4.6

4

1.2

5.3 (1.7 − 16.2)

9.3 (3.0 − 29.6)

1.5 (0.3 − 8.6)

TNF-α-863

        

  CC

66

20.31

115

34.3

1.0

1.0

1.0

  CA + AA

159

48.9

178

53.1

1.6 (1.1 − 2.3)

1.8 (0.8 − 2.2)

0.8 (0.3 − 2.4)

  CC

+

34

10.5

19

5.7

3.1 (1.6 − 5.9)

5.2 (2.5 − 10.5)

1.7 (1.0 − 2.7)

  CA + AA

+

66

20.3

23

6.9

5.3 (3.0 − 9.4)

8.5 (4.6 − 16.0)

1.3 (0.5 − 3.2)

TNF-α-1031

        

  TT

71

21.9

115

34.3

1.0

1.0

1.0

  TC + CC

154

47.4

178

53.1

1.4 (1.0 − 2.0)

1.6 (1.0 − 2.6)

0.7 (0.2 − 2.3)

  TT

+

31

9.5

17

5.1

3.1 (1.6 − 6.1)

6.0 (2.8 − 12.4)

1.2 (0.8 − 2.0)

  TC + CC

+

69

21.2

25

7.5

4.5 (2.6 − 7.9)

9.0 (4.8 − 16.7)

1.0 (0.4 − 2.3)

  1. 1Adjusted for age, sex, and smoking and alcohol drinking status.