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Table 6 Joint effect of HPV16 serology and combined risk genotypes of TNF-α SNPs on risk of OSCC, stratified by smoking

From: Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma

Risk groups1

HPV16 status

Patients

Controls

Adj. OR (95% CI)2

  

(n = 325)

(n = 335)

  

No.

%

No.

%

OSCC

SCCOP

  Never-smokers

 

(n = 99)

(n = 96)

  

  Low-risk group

15

15.2

32

33.3

1.0

1.0

  Medium-risk group

17

17.2

38

39.6

1.0 (0.4 − 2.3)

1.0 (0.2 − 3.1)

  High-risk group

21

21.2

18

18.8

2.3 (1.0 − 5.9)

2.5 (1.0 − 8.6)

  Low-risk group

+

10

10.1

5

5.2

5.4 (1.5 − 19.4)

11.0 (2.6 − 46.8)

  Medium-risk group

+

11

11.1

1

1.0

28.4 (3.2 − 250.2)

51.6 (5.4 − 496.8)

  High-risk group

+

25

25.3

1

2.1

35.6 (7.0 − 180.3)

67.4 (12.0 − 378.5)

Ever-smokers

 

(n = 226)

(n = 239)

  

  Low-risk group

46

20.4

49

20.5

1.0

1.0

  Medium-risk group

36

15.9

91

38.1

0.4 (0.2 − 0.7)

0.5 (0.2 − 1.0)

  High-risk group

90

39.8

65

27.2

1.5 (0.9 − 2.6)

1.5 (0.8 − 2.9)

  Low-risk group

+

17

7.5

8

3.4

2.2 (0.8 − 5.6)

3.6 (1.3 − 10.0)

  Medium-risk group

+

12

5.3

20

8.4

0.7 (0.3 − 1.5)

1.2 (0.5 − 3.1)

  High-risk group

+

25

11.1

6

2.5

4.8 (1.8 − 12.9)

7.4 (2.6 − 21.4)

  1. 1Low-risk group: individuals carrying 0–1 risk genotypes; medium-risk group: individuals carrying 2 risk genotypes; and high-risk group: individuals carrying 3 or 4 risk genotypes.
  2. 2Adjusted for age, sex, and smoking and drinking status.