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Figure 4 | Molecular Cancer

Figure 4

From: Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2–mediated angiogenesis

Figure 4

Western blot analysis of the effect of tylophorine on VEGFR2-mediated downstream signaling. (A) HUVECs were pre-treated with tylophorine followed by the stimulation with 50 ng/mL of VEGF for 20 min. Data were presented as means ± SEM, n = 6. (B). Effect of tylophorine on VEGF-induced MMP-2 secretion from HUVECs after 20 h examined by zymography. Data were presented as means ± SEM, n = 6. (C). Effect of tylophorine on HUVECs intracellular ROS level as detected by DCFH-DA staining assay. Data were presented as means ± SEM, n = 6. ##p < 0.01 VEGF-treated group versus no VEGF-treated group; **p < 0.01; ***p < 0.001 versus VEGF-stimulated group.

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Molecular Cancer

ISSN: 1476-4598