FGFR3 conveys a negative signal in the pancreatic beta cell line BTC. A) BTC cells were cultured in the absence (CT) or in the presence of the neutralizing anti-FGFR3. Alternatively, cells were transiently transfected with a vector overexpressing FGFR3-IIIc or a control vector (CT). B) Tumors were produced from parental BTC cells (n = 12) or clones of BTC cells overexpressing stably FGFR3-IIIc (n = 17). Tumor masses were determined 6 weeks after cells were injected. ***: p < 0.001, **: p < 0.01.