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Table 1 Positions of Phosphorylations of RelA and corresponding kinases

From: The complexity of NF-κB signaling in inflammation and cancer

Kinase

p65 target residue

Effect of phosphate

References

unknown

S205

stimulates transcriptional activity

[54]

MSK1

S276

stimulates transcriptional activity

[55]

PIM1

S276

stimulates transcriptional activity

[56]

PKAc

S276

stimulates transcriptional activity

[57, 58]

unknown

S281

stimulates transcriptional activity

[54]

PKCζ

S311

stimulates transcriptional activity

[59]

GSK-3β

S468

stimulates transcriptional activity

[60]

IKK2

S468; S536

stimulates transcriptional activity and nuclear import

[61, 62]

IKKϵ

S468;S536

stimulates transcriptional activity

[63, 64]

CKII

S529

stimulates transcriptional activity

[65]

CaMKIV

S535

stimulates transcriptional activity

[66]

TBK1

S536

stimulates transcriptional activity

[67]

IKK1

S536

stimulates transcriptional activity and stabilization

[68]

RSK1

S536

decreases IκBα -mediated nuclear export

[69]

ATM

S547

Increased expression of specific genes

[70]

unknown

T254

stabilization and nuclear localization

[71]

unknown

T435

stimulates transcriptional activity

[72]

CHK1

T505

pro-apoptotic effect

[73]