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Table 1 Panel of tested tumor cell lines

From: Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines

Cell line

Tumor type

Genotype

FTI sensitivity

Source

References

HeLa

Cervical

p53 not expressed

Resistant

ECACC

[27]

A375MM

Melanoma

BRafV600E

Resistant

[28, 29]

[28–30]

HT29

Colon

BRafV600E

Sensitive

ATCC

[26, 31, 32]

  

p53R273H

   

A549

Lung

KRasG12S

Sensitive

ATCC

[33]

MCF7

Breast

PI3KCAE545K

Sensitive

ATCC

[34]

  1. Note: wt genes are not indicated.