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Table 1 Panel of tested tumor cell lines

From: Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines

Cell line Tumor type Genotype FTI sensitivity Source References
HeLa Cervical p53 not expressed Resistant ECACC [27]
A375MM Melanoma BRafV600E Resistant [28, 29] [2830]
HT29 Colon BRafV600E Sensitive ATCC [26, 31, 32]
A549 Lung KRasG12S Sensitive ATCC [33]
MCF7 Breast PI3KCAE545K Sensitive ATCC [34]
  1. Note: wt genes are not indicated.