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Table 1 Tumor suppression effect of GE and/or TAM on mouse tumor xenografts

From: Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer

Animal group

Diet and treatment

BWCa(g, mean ± SD)

TVb(mm3mean ± SD)

RTVc(mean)

IRd(%)

Control

Modified AIN-93G diet 7% of corn oil instead of soy oil; no treatment

4.5 ± 1.64

1236.2 ± 195

14.54

-

TAM

Diet is control diet; TAM tablet (25 mg/pellet) was implanted subcutaneously two weeks post-injection

4.9 ± 1.52

1160.5 ± 225.57

14.69

−1

GE

GE diet contains 250 mg genistein/kg of modified AIN-93G diet; no treatment

4.18 ± 1.21

306.9 ± 30.16

7.14

50.89

GE + TAM

Diet is GE diet; TAM tablet (25mg/pellet) was implanted subcutaneously two weeks post-injection

4.38 ± 1.46

24.33 ± 4.04

0.45

96.9

  1. a. Body weight change (BWC) = (BW on sacrificing day)-(BW of experiment initiation); b. Tumor volume (TV) = (length × width2) × 0.532; c. Relative Tumor volume (RTV) = (TV on sacrificing day)/(TV on day 1 of injection); d. Inhibition rate on tumor growth (IR) = {1 - (mean RTV of the treatment group)/(mean RTV of the control group)} · 100.
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Molecular Cancer

ISSN: 1476-4598