USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy

Table 1 Involvement of selected DUBs in the regulation of cancer-related signalling pathways and cellular processes

DUB	Signalling pathway/Process	Substrate
USP2a	Fas and p53	FAS, MDM2, MDMX
	Mitotic progression	Aurora A
	NF-κB	RIP1, TRAF2, TRAF6
	Cell cycle	Cyclin A1
USP4	Wnt	TCF4
	p53	ARF-BP1
	NF-κB	TAK1, TRAF2, TRAF6, RIP1
	TGF-β and AKT	TβRI
	Growth factor receptor pathways	PDK1
USP7	p53	p53, MDM2, MDMX
USP7	Akt	FOXO4, PTEN
USP10	Transcriptional regulation	H2A.Z
USP10	p53	p53
USP29	p53	p53
USP42	p53	p53
USP8/Ubpy	Endosomal sorting	EGFR
	Wg/Wnt	Frizzled
	Hedgehog	Smoothened
AMSH	Endosomal sorting	EGFR
Cezanne	NF-κB	TRAF6, RIP1
CYLD	NF-κB	TRAF2, TRAF6, TRAF7, TAK1, RIP1

Table shows several human DUBs involved in the regulation of different signalling pathways/processes, as well as their reported substrates. An extended version of this Table, including references, is provided as Additional file 1: Table S1.

ISSN: 1476-4598