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Table 2 USP1 over/underexpression in several cancer tissue types

From: USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy

Cancer type

Overexpressed

Underexpressed

Sarcoma

11/15 (73%)

0/15 (0%)

Melanoma

4/6 (67%)

1/6 (17%)

Gastric cancer

5/8 (63%)

0/8 (0%)

Cervical cancer

3/5 (60%)

0/5 (0%)

Brain and CNS cancer

10/20 (50%)

1/20 (5%)

Liver cancer

3/10 (30%)

0/10 (0%)

Other cancer

8/27 (30%)

6/27 (22%)

Lung cancer

4/16 (25%)

0/16 (0%)

Bladder cancer

2/9 (22%)

0/9 (0%)

Myeloma

1/5 (20%)

0/5 (0%)

Colorectal cancer

5/26 (19%)

0/26 (0%)

Head and neck cancer

4/25 (16%)

0/25 (0%)

Esophageal cancer

1/10 (10%)

0/10 (0%)

Kidney cancer

2/20 (10%)

0/20 (0%)

Ovarian cancer

1/11 (9%)

1/11 (9%)

Lymphoma

2/27 (7%)

3/27 (11%)

Breast cancer

1/31 (3%)

1/31 (3%)

Leukemia

0/22 (0%)

4/22 (18%)

Pancreatic cancer

0/8 (0%)

0/8 (0%)

Prostate cancer

0/16 (0%)

1/16 (6%)

  1. The publicly avalilable Oncomine cancer microarray database (accessed in April 2013) was queried to systematically assess USP1 expression levels across different cancer types versus the corresponding normal tissue (Analysis type: Cancer vs Normal). In the “Gene summary view” page, the following thresholds were set: P-value < 0.05; Fold-change > 1.5; Gene-rank, Top 10%. As “Data-type”, mRNA was selected. For each cancer type, the number of analyses that met the thresholds for overexpression or underexpression was recorded, and is shown in the Table as a ratio (and percentage) with respect to the total number of analyses in the database.