Figure 2From: Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stressesSchematic characterization of mutual relations between HIF-1 and p53 pathways under different stress conditions. 1. Activation of hypoxia-inducible factor (HIF-1) during hypoxia; 2. Suppression of HIF-1 by von Hippel Lindau protein (VHL) during normoxia; 3. Downregulation of HIF-1 expression and protein biosynthesis by ataxia-telangiectasia mutated protein (ATM); 4. Stabilization and phosphorylation of p53 triggered by ATM in response to DNA damage; 5. Murine double minute 2 (MDM2)-dependent ubiqutination of p53; 6. Activation of p53 dependent on ATM-mediated phosphorylation of MDM2; 7. Positive regulation of p53 during DNA damage by nucleating ATM mediated by VHL; 8. Downregulation of p53 by HIF-1 under mild hypoxia; 9. Activation of p53 by HIF-1 under severe or/and prolonged hypoxia; 10. Suppression of HIF-1 by p53 under anoxia; 11. Competition of p53 and HIF-1 for binding the cofactors p300 and PCAF during hypoxia.Back to article page