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Table 1 Comparison of radiosensitivity of NSCLC cells treated with RTK inhibitors

From: Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes

Cell line

A549

H460

Treatment

IR

IR + Dasatinib

IR + Axitinib

IR

IR + Dasatinib

IR cp Axitinib

D 0

1.058 ± 0.07

0.920 ± 0.05

1.015 ± 0.03

1.077 ± 0.11

0.914 ± 0.11

1.047 ± 0.12

p (vs IR)

-

0.006

0.149

-

0.009

0.406

ñ

2.773 ± 0.43

1.464 ± 0.30

1.892 ± 0.22

4.454 ± 1.72

2.206 ± 1.13

2.630 ± 0.61

p (vs IR)

-

<0.0001

0.027

-

0.011

0.029

  1. Results were calculated with linear quadratic and single hit multi-target models and presented as D0 –Gy, the dose required to reduce the fraction of survived cells to 37% and ñ (extrapolation number derived by extension of the linear proportion of the radiation survival curve to the ordinate of the graph using a log/linear plot).
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Molecular Cancer

ISSN: 1476-4598