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Table 1 Comparison of radiosensitivity of NSCLC cells treated with RTK inhibitors

From: Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes

Cell line A549 H460
Treatment IR IR + Dasatinib IR + Axitinib IR IR + Dasatinib IR cp Axitinib
D 0 1.058 ± 0.07 0.920 ± 0.05 1.015 ± 0.03 1.077 ± 0.11 0.914 ± 0.11 1.047 ± 0.12
p (vs IR) - 0.006 0.149 - 0.009 0.406
ñ 2.773 ± 0.43 1.464 ± 0.30 1.892 ± 0.22 4.454 ± 1.72 2.206 ± 1.13 2.630 ± 0.61
p (vs IR) - <0.0001 0.027 - 0.011 0.029
  1. Results were calculated with linear quadratic and single hit multi-target models and presented as D0 –Gy, the dose required to reduce the fraction of survived cells to 37% and ñ (extrapolation number derived by extension of the linear proportion of the radiation survival curve to the ordinate of the graph using a log/linear plot).