Table 1 Examples of IMIDs associated with increased risks for cancer
From: Cancer risk in immune-mediated inflammatory diseases (IMID)
IMID | Associated malignancies |
|---|---|
Aplastic anemia | Myeloproliferative disorders [36] |
Autoimmune hepatitis | |
Celiac disease | Non-Hodgkin’s lymphoma, esophageal cancer, Hodgkin’s lymphoma, small bowel carcinoma, stomach cancer [39–41] |
Crohn’s disease | Colorectal and fistula cancer and for cancer of the small bowel, upper gastrointestinal tract, lung, urinary bladder and skin [42–44]. Liver, pancreatic, prostate, testicular, and kidney cancers, nonthyroid endocrine tumors, and leukemia [45]. |
Dermatomyositis | Ovarian, lung, gastric cancer [46] |
Giant cell arteritis | Myeloproliferative disorders [36] |
Immune thrombocytopenic purpura | Myeloproliferative disorders [36] |
Polymyalgia rheumatica | Myeloproliferative disorders [36] |
Primary biliary cirrhosis | Hepatocellular carcinoma [38] |
Psoriasis | Colon cancer [47] and possibly cancer of the urinary bladder, kidney, oropharynx/larynx, esophagus, stomach, liver/gallbladder, vulva, female breast, and pancreas and for leukemia, non-Hodgkin’s lymphoma, and non-melanoma skin cancer [48–57] |
Reiter’s syndrome | Myeloproliferative disorders [36] |
RA | Lymphoma and leukemia, non-melanoma skin cancers [32, 33, 58]; lymphoma and lung cancer [33] |
Sarcoidosis | Rectal, colon, kidney, skin (squamous cell), nonthyroid endocrine cancer; non-Hodgkin’s lymphoma; leukemia [59] |
Sjögren syndrome | lymphoproliferative disorders [46] |
SLE | Hematological malignancies, including non-Hodgkin’s lymphoma, and cancers of the vagina/vulva/cervix, nasopharynx, and kidney [60–62] |
Systemic sclerosis | Lung, skin, esophageal, non-melanoma skin, and liver cancer [40, 46, 63] |
Type 1 diabetes mellitus | |
Ulcerative colitis | Colorectal carcinoma, liver-biliary cancer, and leukemia [42, 66] |