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Table 3 Univariate and multivariate analyses of LDHA expression and patients’ survival

From: Lactate Dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma

Variable Disease-free survival Overall survival
HRa 95% CIb P-value HRa 95% CIb P-value
Univariate analysis (N = 338)
LDHA expression       
  Low 1.00    1.00   
  Moderate 1.12 0.37-3.39 0.83 0.97 0.26-3.59 0.96
  High 10.23 3.68 - 28.41 <0.001 4.04 1.18 -13.85 0.026
Stage (nominal) 7.10 4.29 - 11.75 <0.001 3.57 1.75 - 7.31 <0.001
Histological grade(nominal) 4.27 2.65 - 6.88 <0.001 3.78 1.92 - 7.44 <0.001
Multivariate analysis c (N = 279)
LDHA expression       
  Low 1.00    1.00   
  Moderate 0.90 0.29 - 2.78 0.85 0.92 0.19 - 4.51 0.92
  High 4.30 1.48 - 12.53 0.007 3.46 0.73 - 16.36 0.12
Tumor size (nominal) 1.70 0.86 - 3.37 0.13 0.69 0.26 - 1.87 0.46
Stage (nominal) 3.35 1.89 - 5.94 <0.001 1.86 0.78 - 4.41 0.16
Histological grade(nominal) 2.11 1.13 - 3.96 0.02 3.17 1.17 – 8.60 0.02
Sex 0.70 0.40 - 1.24 0.23 1.14 0.44 - 2.95 0.78
  1. aHazard ratio, estimated from Cox proportional hazard regression model.
  2. bConfidence interval of the estimated HR.
  3. cMultivariate models were adjusted for tumor size, histological grade, sex and tumor stage.