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Table 3 Univariate and multivariate analyses of LDHA expression and patients’ survival

From: Lactate Dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma

Variable

Disease-free survival

Overall survival

HRa

95% CIb

P-value

HRa

95% CIb

P-value

Univariate analysis (N = 338)

LDHA expression

      

  Low

1.00

  

1.00

  

  Moderate

1.12

0.37-3.39

0.83

0.97

0.26-3.59

0.96

  High

10.23

3.68 - 28.41

<0.001

4.04

1.18 -13.85

0.026

Stage (nominal)

7.10

4.29 - 11.75

<0.001

3.57

1.75 - 7.31

<0.001

Histological grade(nominal)

4.27

2.65 - 6.88

<0.001

3.78

1.92 - 7.44

<0.001

Multivariate analysis c (N = 279)

LDHA expression

      

  Low

1.00

  

1.00

  

  Moderate

0.90

0.29 - 2.78

0.85

0.92

0.19 - 4.51

0.92

  High

4.30

1.48 - 12.53

0.007

3.46

0.73 - 16.36

0.12

Tumor size (nominal)

1.70

0.86 - 3.37

0.13

0.69

0.26 - 1.87

0.46

Stage (nominal)

3.35

1.89 - 5.94

<0.001

1.86

0.78 - 4.41

0.16

Histological grade(nominal)

2.11

1.13 - 3.96

0.02

3.17

1.17 – 8.60

0.02

Sex

0.70

0.40 - 1.24

0.23

1.14

0.44 - 2.95

0.78

  1. aHazard ratio, estimated from Cox proportional hazard regression model.
  2. bConfidence interval of the estimated HR.
  3. cMultivariate models were adjusted for tumor size, histological grade, sex and tumor stage.