DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase

Table 2 Dusps genes expression profile from Dusp3-knockout versus WT Matrigel plugs

Gene name	Protein names	Ratio *Dusp3*-KO/WT	*P value*
*Typical Dusps*
Dusp1	MKP1	0.60	0.041*
Dusp2	PAC-1	1.0	0.96
Dusp4	MKP2	0.48	0.18
Dusp5	DUSP5; hVH3; B23	NP
Dusp6	MKP3	1	0.9
Dusp7	MKPX	0.9	0.6
Dusp8	DUSP8	0.97	0.88
Dusp9	MKP4	ND
Dusp10	MKP5	1.5	0.23
Dusp16	MKP7	1.2	0.33
Styxl1	MK-STYX	ND
*Atypical Dusps*
Epm2a	Laforin	ND
Dusp3	VHR	ND
Dusp11	PIR1	1	0.75
Dusp13	MDSP; TMDP; DUSP13	1.8	0.38
Dusp14	MKP6	0.84	0.51
Dusp15	VHY	1.1	0.56
Dusp18	LMW-DSP20	0.54	0.11
Dusp319	SKRP1; LMW-DSP3	1.3	0.057
Dusp21	LMW-DSP21	ND
Dusp22	JSP-1; JKAP; MKPX; VHX	1.4	0.078
Dusp23	LDP-3; VHZ	0.85	0.04*
Dusp26	MKP8, NEAP	1.3	0.71
Dupd1	DUPD1	2.5	0.18
Dusp28	VHP	1.1	0.31
Styx	STYX	1.1	0.43

Data presented in this table are extracted from a genome-wide microarray dataset obtained using Illumina’s multi sample format Mouse WG-6 V2 BeadChip. Data are presented as the ratio of the average values obtained from 2 pools of 3 Dusp3-knockout each on 2 pools of 3 WT mice each and the corresponding p-value. (*p < 0.05 determined using unpaired student’s t test). ND: not detected. NP: no probe/not present on the microarray chip.

ISSN: 1476-4598