Figure 8

Working model for the tumor suppressive function of Fbxw7 and its downstream pathway. Fbxw7 promotes both apoptosis and the growth arrest of HCC through promoting YAP ubiquitination and proteasomal degradation.
Working model for the tumor suppressive function of Fbxw7 and its downstream pathway. Fbxw7 promotes both apoptosis and the growth arrest of HCC through promoting YAP ubiquitination and proteasomal degradation.