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Table 1 Clinical correlation of Fbxw7 expression in HCC

From: Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma

Clinicopathologic features Total no. of patients, n = 60 No. of patients P
Fbxw7 negative Fbxw7 positive
Age (y) <50 19 13 6 0.365
≥50 41 23 18
Sex Male 48 28 20 0.598
Female 12 8 4
HBV Absent 14 9 5 0.709
Present 46 27 19
Serum AFP level (ng/mL) <400 24 14 10 0.830
≥400 36 22 14
Tumor size (cm) <5 21 7 14 0.002*
≥5 39 29 10
No. of tumor nodules 1 45 24 21 0.068
≥2 15 12 3
Cirrhosis Absent 28 17 11 0.916
Present 32 19 13
Venous infiltration Absent 31 14 17 0.015*
Present 29 22 7
Edmondson-Steiner grading I + II 18 6 12 0.006*
III + IV 42 30 12
TNM tumor stage I + II 40 19 21 0.005*
III + IV 20 17 3
  1. HCC, hepatocellular carcinoma; HBV, hepatitis B virus; AFP, alpha-fetoprotein; TNM, tumor-node-metastasis. *Statistically significant.