Molecular Cancer

Table 1 Clinical correlation of Fbxw7 expression in HCC

From: Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma

Clinicopathologic features		Total no. of patients, n = 60	No. of patients		P
Clinicopathologic features		Total no. of patients, n = 60	Fbxw7 negative	Fbxw7 positive	P
Age (y)	<50	19	13	6	0.365
Age (y)	≥50	41	23	18	0.365
Sex	Male	48	28	20	0.598
Sex	Female	12	8	4	0.598
HBV	Absent	14	9	5	0.709
HBV	Present	46	27	19	0.709
Serum AFP level (ng/mL)	<400	24	14	10	0.830
Serum AFP level (ng/mL)	≥400	36	22	14	0.830
Tumor size (cm)	<5	21	7	14	0.002*
Tumor size (cm)	≥5	39	29	10	0.002*
No. of tumor nodules	1	45	24	21	0.068
No. of tumor nodules	≥2	15	12	3	0.068
Cirrhosis	Absent	28	17	11	0.916
Cirrhosis	Present	32	19	13	0.916
Venous infiltration	Absent	31	14	17	0.015*
Venous infiltration	Present	29	22	7	0.015*
Edmondson-Steiner grading	I + II	18	6	12	0.006*
Edmondson-Steiner grading	III + IV	42	30	12	0.006*
TNM tumor stage	I + II	40	19	21	0.005*
TNM tumor stage	III + IV	20	17	3	0.005*

HCC, hepatocellular carcinoma; HBV, hepatitis B virus; AFP, alpha-fetoprotein; TNM, tumor-node-metastasis. *Statistically significant.

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