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Table 2 Multivariate Cox regression analysis of the overall and disease-free 5-year survival of 60 HCC patients

From: Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma

Variables

Overall survival

Disease-free survival

HR

95% CI

P

HR

95% CI

P

Age

2.113

0.888-5.030

0.091

1.670

0.787-3.545

0.182

Sex

0.749

0.339-1.652

0.474

1.031

0.492-2.162

0.936

HBV

1.846

0.694-4.908

0.219

1.971

0.827-4.696

0.126

No. of tumor nodules

1.092

0.500-2.386

0.824

0.889

0.438-1.805

0.744

Tumor size

0.411

0.160-1.056

0.065

0.481

0.211-1.098

0.082

Venous infiltration

1.539

0.722-3.284

0.264

1.892

0.940-3.808

0.074

Serum AFP level

0.883

0.412-1.895

0.749

0.953

0.483-1.880

0.889

Cirrhosis

1.288

0.651-2.548

0.468

1.313

0.711-2.423

0.384

Edmondson-Steiner grading

0.771

0.322-1.846

0.560

0.702

0.338-1.458

0.342

TNM tumor stage

3.576

1.251-10.211

0.017*

3.532

1.266-9.858

0.016*

Fbxw7 expression in tumor

0.253

0.081-0.790

0.018*

0.228

0.078-0.666

0.007*

  1. HBV, hepatitis B virus; AFP, alpha-fetoprotein; TNM, tumor-node-metastasis; HR, hazard ratio; CI, confidence interval. *Statistically significant.