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Figure 3 | Molecular Cancer

Figure 3

From: Combined targeting of TGF-β1 and integrin β3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer

Figure 3

Integrin β3 silencing in H157 cells significantly diminishes cell movement across LEC monolayers. (A) Microphotographs showing the adhesion of TGF-β-pretreated H157 cells (integrin-competent and integrin-deficient) to LEC monolayers (63× water objective). (B) Average distance covered and speed of TGF-β-pretreated H157 cells (integrin-competent and integrin-deficient): ** p = 0.001, one-way ANOVA with Dunnett’s multiple comparison test. (C) Representation of cell directionality for one representative cell from each group. A minimum of 30 cells were analyzed per group.

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