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Figure 4 | Molecular Cancer

Figure 4

From: Combined targeting of TGF-β1 and integrin β3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer

Figure 4

H157 cell transmigration across endothelial monolayers is inhibited by blocking antibodies against the β3 integrin ligands L1CAM and CD31. Quantification of the number of TGF-β-pretreated β3 integrin-competent (A) and β3 integrin-deficient (B) H157 cells transmigrating across LEC monolayers in the presence of blocking antibodies against the L1CAM RGD binding region (L1.35.9 mAb), the L1CAM homotypic binding region (L1 9.3 mAb) and CD31: **p = 0.001, one-way ANOVA with Dunnett’s multiple comparison test.

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