Table 1 Normalised cytokine data in the combined training and test datasets
From: Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease
| Â | Median (95% CI) | P value | |||||||
|---|---|---|---|---|---|---|---|---|---|
Analyte | PDAC (n = 127) | HC (n = 45) | CP (n = 49) | BBO (n = 20) | CP + BBO (n = 69) | PDAC vs. HC | PDAC vs. CP | PDAC vs. BBO | PDAC vs. CP + BBO |
CA19-9 | 0.01 | -5.01 | -2.7 | -0.82 | -2.25 | <0.001 | <0.001 | NS | <0.001 |
(-1.0 to 0.2) | (-5.4 to -4.6) | (-3.5 to -2.2) | (-2.6 to 0.5) | (-3.2 to -1.6) | |||||
Eotaxin | 0.48 | 0.23 | 0.53 | -0.08 | 0.45 | NS | NS | <0.05 | NS |
(0.3 to 0.6) | (-0.2 to 0.5) | (0.2 to 0.8) | (-0.5 to 0.7) | (-0.03 to 0.7) | |||||
IL-1b | 0.23 | 0.16 | 0.27 | 0.14 | 0.17 | NS | NS | <0.05 | NS |
(0.1 to 0.4) | (0.08 to 0.3) | (0.04 to 0.6) | (-0.5 to 0.5) | (0.05 to 0.4) | |||||
IL-1ra | 0.72 | 0.18 | 0.78 | 0.06 | 0.59 | <0.05 | NS | NS | NS |
(0.4 to1.0) | (-0.3 to 0.4) | (0.4 to 1.3) | (-1.5 to 1.5) | (0.2 to 1.0) | |||||
IL-6 | 1.25 | 0.41 | 1.65 | 1.78 | 1.71 | <0.001 | NS | NS | NS |
| Â | (1.0 to 1.5) | (0.1 to 0.7) | (1.2 to 2.1) | (1.0 to 2.5) | (1.2 to 2.0) | Â | Â | Â | Â |
IL-8 | 0.95 | 0.02 | 0.54 | 0.38 | 0.51 | <0.001 | <0.001 | NS | <0.001 |
| Â | (0.8 to1.2) | (-0.3 to 0.06) | (0.3 to 0.8) | (-0.4 to 1.1) | (0.3 to 0.8) | Â | Â | Â | Â |
IP-10 | -1.85 | -2.99 | -2.6 | -2.52 | -2.59 | <0.001 | <0.001 | NS | <0.001 |
| Â | (-2.0 to -1.7) | (-3.3 to -2.7) | (-2.9 to -2.3) | (-2.9 to -1.5) | (-2.8 to -2.3) | Â | Â | Â | Â |
MCP-1 | 0.31 | 0.44 | 0.92 | 0.64 | 0.81 | NS | NS | NS | NS |
| Â | (0.2 to 0.6) | (-0.02 to 0.6) | (0.3 to 1.2) | (-0.2 to 1.6) | (0.3 to 1.2) | ||||
MIP-1b | 0.31 | -0.45 | 0.02 | -0.28 | -0.06 | <0.001 | NS | <0.05 | <0.01 |
| Â | (0.2 to 0.4) | (-0.6 to -0.2) | (-0.3 to 0.4) | (-0.5 to 0.2) | (-0.3 to 0.2) | ||||
PDGF | 0.44 | 0.31 | 0.21 | -0.62 | 0.09 | NS | NS | <0.01 | <0.01 |
| Â | (0.2 to 0.5) | (0.1 to 0.4) | (-0.02 to 0.5) | (-1.5 to 0.2) | (-0.18 to 0.4) | ||||