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Table 1 Normalised cytokine data in the combined training and test datasets

From: Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease

  Median (95% CI) P value
Analyte PDAC (n = 127) HC (n = 45) CP (n = 49) BBO (n = 20) CP + BBO (n = 69) PDAC vs. HC PDAC vs. CP PDAC vs. BBO PDAC vs. CP + BBO
CA19-9 0.01 -5.01 -2.7 -0.82 -2.25 <0.001 <0.001 NS <0.001
(-1.0 to 0.2) (-5.4 to -4.6) (-3.5 to -2.2) (-2.6 to 0.5) (-3.2 to -1.6)
Eotaxin 0.48 0.23 0.53 -0.08 0.45 NS NS <0.05 NS
(0.3 to 0.6) (-0.2 to 0.5) (0.2 to 0.8) (-0.5 to 0.7) (-0.03 to 0.7)
IL-1b 0.23 0.16 0.27 0.14 0.17 NS NS <0.05 NS
(0.1 to 0.4) (0.08 to 0.3) (0.04 to 0.6) (-0.5 to 0.5) (0.05 to 0.4)
IL-1ra 0.72 0.18 0.78 0.06 0.59 <0.05 NS NS NS
(0.4 to1.0) (-0.3 to 0.4) (0.4 to 1.3) (-1.5 to 1.5) (0.2 to 1.0)
IL-6 1.25 0.41 1.65 1.78 1.71 <0.001 NS NS NS
  (1.0 to 1.5) (0.1 to 0.7) (1.2 to 2.1) (1.0 to 2.5) (1.2 to 2.0)     
IL-8 0.95 0.02 0.54 0.38 0.51 <0.001 <0.001 NS <0.001
  (0.8 to1.2) (-0.3 to 0.06) (0.3 to 0.8) (-0.4 to 1.1) (0.3 to 0.8)     
IP-10 -1.85 -2.99 -2.6 -2.52 -2.59 <0.001 <0.001 NS <0.001
  (-2.0 to -1.7) (-3.3 to -2.7) (-2.9 to -2.3) (-2.9 to -1.5) (-2.8 to -2.3)     
MCP-1 0.31 0.44 0.92 0.64 0.81 NS NS NS NS
  (0.2 to 0.6) (-0.02 to 0.6) (0.3 to 1.2) (-0.2 to 1.6) (0.3 to 1.2)
MIP-1b 0.31 -0.45 0.02 -0.28 -0.06 <0.001 NS <0.05 <0.01
  (0.2 to 0.4) (-0.6 to -0.2) (-0.3 to 0.4) (-0.5 to 0.2) (-0.3 to 0.2)
PDGF 0.44 0.31 0.21 -0.62 0.09 NS NS <0.01 <0.01
  (0.2 to 0.5) (0.1 to 0.4) (-0.02 to 0.5) (-1.5 to 0.2) (-0.18 to 0.4)
  1. Median normalised log2 transformed data are presented for each analyte; the 95% CI are given in brackets. PDAC = Cancer, CP = Chronic Pancreatitis, BBO = Benign Biliary Obstruction. Wilcoxon signed rank tests were used to generate p-values for group comparisons. NS - non-significant.