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Figure 1 | Molecular Cancer

Figure 1

From: Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells

Figure 1

miR-638 exhibits reduced expression in CRC tissues. A) We analyzed the expression levels of miR-638 in 36 pairs of CRC tissues and observed a 22.98% decrease in expression in the CRC tissue samples compared with adjacent noncancerous tissue samples, p < 0.0001 (paired t-test). B) miR-638 expression was downregulated in 83.33% of the 36 pairs of tissues. C) miR-638 expression was correlated with tumor differentiation, and the miR-638 expression level was downregulated to 27.28% in moderately differentiated samples and to 61.29% in poorly differentiated samples compared with its levels in well-differentiated samples. H, M, and L indicate high, moderate, and low differentiation grades, respectively. D) miR-638 expression was reduced in CRC cell lines compared with normal colon tissue samples.

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Molecular Cancer

ISSN: 1476-4598