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Figure 3 | Molecular Cancer

Figure 3

From: Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells

Figure 3

The inhibition of miR-638 induces a mesenchymal-like transition in SW1116 cells. A) The overexpression of miR-638 mimics in SW1116 cells increased cell-to-cell contacts, and the overexpression of the antagomiR to miR-638 promoted lamellipodium stretching and decreased cell-to-cell contacts. Cells were stained for F-actin (red). Nuclei were counterstained with DAPI (blue). Scale bar, 20 μm. B) The overexpression of miR-638 mimics in SW1116 cells increased the expression of the epithelial cell marker ZO-1/E-cadherin and decreased the expression of the mesenchymal cell marker vimentin. In contrast, the expression of the antagomiR to miR-638 decreased ZO-1/E-cadherin expression and increased vimentin expression.

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Molecular Cancer

ISSN: 1476-4598